Spontaneous remission of sexually transmitted diseases must be considered in randomised controlled trials
نویسندگان
چکیده
Comparison of microbicides for efficacy in protecting mice against vaginal challenge with herpes simplex virus type 2, cytotoxicity, antibacterial properties, and sperm immobilization. Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model. ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells. Detection of herpes simplex virus type 2-specific immunoglobulin G antibodies in African sera by using recombinant gG2, Western blotting, and gG2 inhibition. Patterns and predictors of adherence to diaphragm use in a phase III trial in sub-Saharan Africa: a trajectory analysis.
منابع مشابه
Prevention of HIV and sexually transmitted diseases in high risk social networks of young Roma (Gypsy) men in Bulgaria: randomised controlled trial.
OBJECTIVE To determine the effects of a behavioural intervention for prevention of HIV and sexually transmitted diseases that identified, trained, and engaged leaders of Roma (Gypsy) men's social networks to counsel their own network members. DESIGN A two arm randomised controlled trial. SETTING A disadvantaged, impoverished Roma settlement in Bulgaria. PARTICIPANTS 286 Roma men from 52 s...
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There is an urgent need for well designed randomised trials to assess the impact of behavioural interventions at both individual and community levels in developed and developing countries. The relative lack of such studies partly reflects the particular challenges of applying randomised trials in this area. Although there are obvious differences between clinical and behavioural interventions, t...
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BACKGROUND Effective condom use can prevent sexually transmitted infections (STIs) and unwanted pregnancy. We conducted a systematic review and methodological appraisal of randomised controlled trials (RCTs) of interventions to promote effective condom use. METHODS We searched for all RCTs of interventions to promote effective condom use using the Cochrane Infectious Diseases Group's trials r...
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The development of non-invasive tests for evidence of current or past infection offers new prospects for carrying out population studies of sexually transmitted infection (STI) epidemiology, and for improved understanding of the behavioural and biological determinants of STI transmission. In turn this may guide screening, treatment, and behavioural interventions. The evidence base for many inte...
متن کاملEffectiveness of female controlled barrier methods in preventing sexually transmitted infections and HIV: current evidence and future research directions.
OBJECTIVES To evaluate evidence for the effectiveness of female controlled physical and chemical barrier methods in preventing STI/HIV transmission, to examine recent reviews on microbicide development, and to highlight promising research directions. To discuss challenges in conducting effectiveness research and in translating results to public health intervention. METHODS Systematic review o...
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